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Vol. 4,  Special Issue(Bi-yearly) -  Paper Submission  Deadline: 20th  December 2019


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ANTI-INFLAMMATORYACTIVITY OF SOME MEDICINAL PLANT EXTRACTS ON ALBINO MICE

Abstract

Abstract: Herbal therapy is well recognized across world and in many cultures. Even till 21 Century it accounts as an
unwritten science in rural world to treat many diseases. Like other chronic conditions, inflammatory diseases are
standing first in a row getting global attention. Inflammation includes diapedesis resulting in migration of the white blood
cells in inflamed part and protecting body from infection with foreign organisms like bacteria and viruses. Several
reports over crude plant extracts have shown to be effective in such cases. The action of poly-herbs differs in many
respects from the actions of single pure drugs or synthetic drugs. The activity of these crude drugs depends on several
factors like method of administration, potentiality and safety. Since methanol is the most common and efficient solvent as
compared to chloroform and petroleum ether for preparing drug formulations. By the other hand leafs of Aloe vera L.,
Lawsonia inermis L. and Vitex negundo L. are well known for their biological activities. During present investigation
57.90 percent anti-inflammatory activity was seen with crude extract of Aloe vera L., similarly Lawsonia inermis L. alone
showed 51.75 percent activity, whereas Vitex negundo L. showed highest topical anti-inflammatory activity i.e. 58.78
percent. All crude drugs showed activity at 200 mg/kg per body weight of albino mice. Modified mercury displacement
method proves to be very effective for the evaluation of anti-inflammatory activity using mice paw edema test.
Keywords: Anti-inflammatory activity, Albino mice, Aloe vera L., Lawsonia inermis L., Mercury displacement, Paw edema Vitex
negundo L.

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