Abstract

ABSTRACT:  Oral routes of drug administration have wide acceptance up to50-60% of total dosage forms. Solid dosage forms are popular because of ease ofadministration, accurate dosage, selfmedication, pain avoidance and mostimportantly the patient compliance. Fast dissolving drug delivery system offersa solution for those patients having difficulty inswallowing tablet. In the present study, an attempt has been made to formulatefast dissolving tablets of Pantoprazole Sodium Sesquihydrate usingsuperdisintegrants such as Croscarmellose sodium (Ac‐Di‐Sol), Sodium starch glycolate (Explotab) and Crosspovidone bydirect compression technique. The prepared tablets were evaluated for hardness,friability, wetting time, weight variation, invitro disintegration time and invitro dissolution study. The hardness of the tablets was in the range of3.0 ‐ 4.0 Kg/cm². The percentage friability of the tablets wasless than one. Weight variation test results showed that the tablets weredeviating from the average weight within the permissible limits of ±7.5 %. Drugcontent uniformity study results showed the uniform dispersion of the drugthroughout the formulation i.e.  98.54%to 101.23%. Tablets containing Crosspovidone (F9) showed better disintegratingcharacter along with the rapid release(99.83% drug within 4 minutes). No appreciable difference was found between theformulations containing other two superdisintegrants. Crosspovidone was foundto be better suited for the formulation of mouth dissolving tablet ofPantoprazole Sodium Sesquihydrate compared to other superdisintegrarnts used inthestudy.

Keywords: Mouth‐dissolving tablets, Pantoprazole Sodium Sesquihydrate,Superdisintegrants